p53 Cocktail; Clones Pab 1801 plus DO-7
Clone: Pab1801 & DO-7
Isotype: IgG1 & IgG2b, Kappa
MW: 53 kD
Species Reactivity: Human
Positive Control: About 50% of breast carcinomas are positive for p53, especially those lacking estrogen and/or progesterone receptor, or with high proliferation index.
Specificity: This antibody reacts with wild as well as mutant types of p53 protein. It recognizes an epitope in the N-terminus of p53 protein. p53 is a 53 kD phosphoprotein known as tumor suppressor gene product. About 50% of breast carcinomas are positive for p53 especially those lacking estrogen and/or progesterone receptors. This antibody can be demonstrated in 22-76% of colon, stomach, bladder, breast, lung and testes cancers. Its epitope maps within the N-terminus (aa 32-79) of p53.