Laminin; Clone 4C7
Species: Mouse Monoclonal
MW: 100 kD
Species Reactivity: Human. Not reactive with mouse or rat.
Specificity: The basement membrane (BM) is a component of the extracellular matrix and is composed of a variety of proteins, of which laminin is the most prevalent. Laminin is synthesized by fibroblasts in epithelial and endothelial cells, as well as smooth muscle cells. This protein normally contributes to the regulation of cell growth, cell attachment to the BM and to the morphology of cells and their urigation.
The monoclonal labels trophoblastic cells of the villous trophoblastic epithelium in the placenta, and epithelia and BM in normal tonsil. Extensive studies of a variety of invasive and non-invasive carcinomas, including their benign counterparts, demonstrated a lack of immunoreactivity for laminin in the majority of invasive carcinomas. Benign or non-invasive lesions showed intact BM.