NKX2.2 (Neuroendocrine & Ewing Sarcoma Marker); Clone NX2/294 (Concentrate)
Immunogen: Recombinant human NKX2.2 protein
Isotype: IgG2b, kappa
Species Reactivity: Human, Mouse, Rat and Chicken. Others not known.
Positive Control: Pancreas or Ewing sarcoma.
Specificity: The NKX2.2 protein was identified as a target of EWS-FLI-1, the fusion protein specific to Ewing sarcoma, and was shown to be differentially upregulated in Ewing sarcoma on the basis of array-based gene expression analysis. It acts as a valuable marker for Ewing sarcoma, with a sensitivity of 93% and a specificity of 89%, and aids in the differential diagnosis of small round cell tumors.