CD35 / CR1 (Follicular Dendritic Cell Marker); Clone E11 (Concentrate)
Immunogen: Intact human monocytes
Isotype: IgG1, kappa
Species Reactivity: Human, Baboon, Cynomolgus Monkey, Rhesus Monkey. Others not known.
Positive Control: Follicular dendritic cells (FDC) in tonsil.
Specificity: Recognizes a protein of 210-220kDa, which is identified as the complement receptor 1 (CR1)/CD35. This antibody is specific for a site in CR1 that is distal from the C3b-binding site, so that it is unable to block CR1 activity. It is highly specific to CR1 and shows no cross-reaction with CR2. This antibody labels follicular dendritic cells and follicular dendritic cell sarcoma.