gp100 / Melanosome / PMEL17 / SILV (Melanoma Marker); Clone HMB45 & PMEL/783 (Concentrate)
Immunogen: Extract of pigmented melanoma metastases from lymph nodes (HMB45); Recombinant human SILV protein (PMEL/783)
Clone: HMB45 & PMEL/783
Isotype: IgG1, kappa (HMB45); IgG1, kappa (PMEL/783)
Species Reactivity: Human. Others not tested.
Positive Control: SK-MEL-28 cells or Melanoma.
Specificity: By immunohistochemistry, this antibody specifically recognizes a protein in melanocytes and melanomas. This antibody reacts with junctional and blue nevus cells and variably with fetal and neonatal melanocytes. Intradermal nevi, normal adult melanocytes, and non-melanocytic cells are negative. It does not stain tumor cells of epithelial, lymphoid, glial, or mesenchymal origin. This antibody also stains Angiomyolipoma (PEComa).