Cytokeratin, High Molecular Weight; Clone 34bE12 (Concentrate)
Immunogen: Solubilized keratin extract from human stratum corneum
Isotype: IgG1, kappa
Species Reactivity: Human, Mouse, and Rat. Others not known.
Positive Control: PC12 cells, skin, prostate carcinoma.
Specificity: This antibody recognizes CK1, CK5, CK10, and CK14. In normal epithelia, it stains stratified epithelia, myoepithelial cells, and basal cells in the prostate gland and bronchi. This antibody shows no reactivity with hepatocytes, pancreatic acinar cells, proximal renal tubules, or endometrial glands; there is no reactivity with cells derived from simple epithelia. Mesenchymal tumors, lymphomas, melanomas, neural tumors, and neuroendocrine tumors are negative with this antibody.