CD23, B-Cell; Clone MHM6
Isotype: IgG1, Kappa
Specificity: In lymphoid tissue, the antibody labels a variable proportion of mantle zone lymphocytes and a fraction of dendritic reticulum cells. In lymph nodes with progressive germinal centre transformation, the number and staining intensity of small follicular lymphocytes are increased. Essentially no staining is seen on splenic marginal zone lymphocytes.
The CD23 antigen is expressed on neaoplatic cells from cases of B-Cell chronic lymphocytic leukemia and some cases of centroblastic/centrocytic lymphoma, but not in other types of lymphoid neoplasms.