p53; Clone DO-7 (Ready-To-Use)
Immunogen: Recombinant human wild type p53 protein expressed in E. coli.
MW: 53 kD
Species Reactivity: Human, Monkey, and Cow. Others not known.
Positive Control: MDA-MB-231 Cells. Breast or colon carcinoma. About 50% of breast carcinomas are positive for p53, especially those lacking estrogen and/or progesterone receptor, or with high proliferation index.
Specificity: Recognizes a 53kDa protein, which is identified as p53 suppressor gene product. It reacts with the mutant as well as the wild type form of p53. Its epitope maps within the N-terminus (aa 37-45) of p53.