Renal Cell Carcinoma (RCC); Clone 66.4.C2 (Ready-To-Use)
Isotype: Mouse IgG2b, Kappa
Species Reactivity: Human, Horse. Others not tested.
Positive Control: Kidney.
Specificity: The actual protein recognized by RCC-ma antibody is a 200 kDa glycoprotein (gp200) expressed in renal epithelial cells. In normal tissue, the renal cell carcinoma/RCC-ma/gp200 antibody stains the brush border of proximal renal tubules in human kidneys. Gp200 is also expressed in some non-kidney tissues including breast tubules and ducts, the surface of epididymal tubular epithelia, and the colloid of thyroid follicles. However because of the reported high expression of gp200 in renal cell carcinoma, gp200 is most commonly referred to as Renal Cell Carcinoma Marker.