Bcl-6 (Follicular Lymphoma Marker); Clone PG-B6p (Ready-To-Use)
Species: Mouse Monoclonal
Isotype: IgG1, kappa
Species Reactivity: Human, rabbit, rat, swine, calf, and lamb.
Positive Control: Tonsil
Cellular Localization: Nuclear
Specificity: In normal tonsil the antibody reacts with the nuclei of centroblasts and centrocytes in germinal centers. No reactivity is observed with other germinal center cells, e.g. plasma cells, macrophages, or follicular dendritic cells. Approximately 10% of germinal center T cells are stained with the antibody. The staining pattern of normal spleen B and T cell compartments are similar to that of tonsil. A faint nuclear staining is observed in squamous epithelia in the tonsil, thymus, and skin. In tumor cells the antibody shows strong nuclear labelling of Bcl-6 protein in follicular lymphomas, diffuse large B cell lymphomas, Bufkitt's lymphomas, and nodular, lymphocyte-predominant Hodgkin's disease.