Cyclin D1; Clone DCS-6 (Ready-To-Use)
Designation: Mouse Monoclonal
Isotype: IgG2a, Kappa
Species Reactivity: Human.
Cellular Localization: Nuclear.
Positive Control: Mantle cell lymphoma and breast carcinoma.
Specificity: The DCS-6 antibody is specific for cyclin D1, and has been key in elucidating the function and involvement of cyclin D1 in oncogenesis. Results with this antibody have helped to show that Cyclin D1 is over expressed in many different kinds of cancer. For example, about 50-70% of mantle cell lymphomas and 40% of breast carcinomas are cyclin D1.