Cytokeratin 8 (KRT8); Clone TS1 (Concentrate)
Immunogen: Keratin preparation from a human carcinoma
Isotype: IgG1, kappa
Species Reactivity: Human. Does not react with Rat. Others not known.
Positive Control: MCF-7 or A431 cells. Skin, colon, lung, or breast carcinoma.
Specificity: The epitope of this antibody is located between aa 343-357. Anti-CK8 does not react with skeletal muscle or nerve cells. Epithelioid sarcoma, chordoma, and adamantinoma show strong positivity corresponding to that of simple epithelia (with antibodies against CK8, CK18 and CK19). Reportedly, anti-CK8 is useful for the differentiation of lobular ("ring-like, perinuclear") from ductal ("peripheral-predominant") carcinoma of the breast.