beta-Catenin (p120); Rabbit Polyclonal (Concentrate)
Immunogen: A synthetic peptide from the middle of beta-Catenin (p120) protein
Species Reactivity: Human and Mouse. Others not known.
Positive Control: HeLa or MCF-7 cells. Breast carcinoma.
Specificity: Immuno-staining of beta-catenin and E-cadherin is helpful in the accurate identification of ductal and lobular neoplasms, including a distinction between low-grade ductal carcinoma in situ (DCIS) and lobular carcinoma. Additionally, some rectal and gastric adenocarcinomas demonstrate diffuse cytoplasmic beta-catenin staining and a lack of membranous staining, mimicking the staining pattern observed with lobular breast carcinomas.