MUC1 / EMA / CD227 (Epithelial Marker); Clone GP1.4 & E29 (Concentrate)
Immunogen: Human milk fat globule membranes (GP1.4); Delipidated extract of human milk fat globule membranes (E29).
Clone: GP1.4 & E29
Isotype: IgG1, kappa (GP1.4); IgG2a, kappa (E29)
Species Reactivity: Human. Reacts moderately with Pig and Dog. Others not known.
Positive Control: Breast or colon carcinoma.
Specificity: In Western blotting, this antibody recognizes proteins in a MW range of 265-400kDa, identified as different glycoforms of MUC1. This antibody reacts with the DTRP epitope within the tandem repeats. In immunohistochemical assays, it superbly stains routine formalin/paraffin carcinoma tissues. An antibody to MUC1 is useful as a pan-epithelial marker for detecting early metastatic loci of carcinoma in bone marrow or liver.