Neurofilament (NF-L) (Neuronal Marker); Clone NFL/736 (Concentrate)
Immunogen: Recombinant human NF-L protein
Species Reactivity: Human, Rat, Pig, Cow and Chicken. Others not known.
Positive Control: Brain, Neuroblastoma.
Specificity: This antibody reacts with a 68kDa protein, identified as the light subunit of neurofilaments (NF-L). Anti-neurofilament stains a number of neural, neuroendocrine, and endocrine tumors. Neuromas, ganglioneuromas, gangliogliomas, ganglioneuroblastomas, and neuroblastomas stain positively for anti-neurofilament. Neurofilaments are also present in paragangliomas as well as adrenal and extra-adrenal pheochromocytomas. Carcinoids, neuroendocrine carcinomas of the skin, and oat cell carcinomas of the lung also express neurofilament.