NGF-Receptor (p75) / CD271 (Soft Tissue Tumor Marker); Clone NGFR5 (Concentrate)
Immunogen: NGFR from A875 melanoma cells
Isotype: IgG1, kappa
Species Reactivity: Human, Monkey, Baboon, Cat, Rabbit and Ferret. Does not react with Mouse and Rat. Others not known.
Positive Control: Neuronal axons, Schwann cells, and perineural cells of peripheral nerves, or tumors of nerve sheath differentiation, e.g. Schwannoma, Neurofibroma. Soma and axons of sensory neurons, and ganglionic satellite cells. Melanomas.
Specificity: Recognizes a glycoprotein of 75kDa, identified as the low affinity Nerve Growth Factor (NGF) Receptor (p75, NGFR) or Neurotrophin Receptor (p75, NTR). Its epitope resides within aa 1-160 of the extracellular domain of NGFR/NTR.