CD45RO (T-Cell Marker); Clone UCHL-1 (Concentrate)
Immunogen: Cultured human T-cells from an IL-2-dependent T-cell line (CA1)
Isotype: IgG2a, kappa
Species Reactivity: Human, Chimpanzee, Common Marmoset. Others not known.
Positive Control: CCRF-CEM, Jurkat or MOLT-4 cells. Paracortex in a tonsil or a reactive lymph node.
Specificity: This antibody recognizes a 180-185kDa protein, identified as an isoform of leukocyte common antigen (CD45RO) (4th Leucocyte Typing Workshop: Code No. N31). The epitope recognized by this antibody is sensitive to neuraminidase digestion. This antibody reacts with mature activated T-cells, most thymocytes, and a sub-population of resting T-cells within both CD4 and CD8 subsets. It shows no reactivity with normal B-cells or natural killer cells, but reacts with granulocytes and monocytes.