MUC6 (Mucin 6 / Gastric Mucin); Clone CLH5 (Concentrate)
Immunogen: A synthetic peptide of the Gastric Mucin 6 tandem repeat sequence
Isotype: IgG1, kappa
Species Reactivity: Human. Others not known.
Positive Control: Stomach
Specificity: Mucin 6 expression is highest in the stomach and gall bladder, with lower expression in the terminal ileum and right colon. In gastric cancer, Mucin 6 has an altered expression. In normal stomach, Mucin 6 is associated with Lewis type 2 antigens; Mucin 6 is also expressed in gastric metaplasia, duodenum, and pancreas. Mucin 6 is a secretory mucin, located in the deeper mucosal folds of human gall bladder, and its expression is altered with increasing degrees of inflammation.