Actin, Smooth Muscle (Leiomyosarcoma Marker); Clone 1A4 (Concentrate)
Immunogen: N-terminal decapeptide of alpha smooth muscle isoform of actin and conjugated to KLH.
Isotype: IgG2a, kappa
Species Reactivity: Human, Baboon, Monkey, Cow, Pig, Sheep, Goat, Cat, Dog, Rabbit, Mouse, Rat, Guinea Pig and Chicken. Others not known.
Positive Control: Blood vessels in all tissues, smooth muscle or leiomyosarcoma.
Specificity: This MAb is highly specific to actin from smooth muscles. Its epitope lies in the first four N-terminal amino acids. This MAb does not stain cardiac or skeletal muscle; however, it does stain myofibroblasts and myoepithelial cells. In most cases of rhabdomyosarcoma, this antibody yields negative results whereas anti-muscle specific actin and myogenin are positive. Leiomyosarcomas are positive only with anti-muscle specific actin and anti-smooth muscle actin and are negative with anti-myogenin.