Actin, Smooth Muscle (Leiomyosarcoma Marker); Clone ACTA2/791 (Concentrate)
Immunogen: Recombinant human ACTA2 protein
Isotype: IgG2a, kappa
Species Reactivity: Human. Shows a broad reactivity.
Positive Control: Blood vessels in all tissues, smooth muscle or leiomyosarcoma.
Specificity: This MAb is highly specific to actin from smooth muscles. This MAb does not stain cardiac or skeletal muscle; however, it does stain myofibroblasts and myoepithelial cells. In most cases of rhabdomyosarcoma, this antibody yields negative results whereas anti-muscle specific actin and myogenin are positive. Leiomyosarcomas are positive only with anti-muscle specific actin and anti-smooth muscle actin and are negative with anti-myogenin.