Cytokeratin 14 (KRT14) (Squamous Cell Marker); Clone LL002 (Concentrate)
Immunogen: A synthetic peptide of 15 amino acids from the C-terminus of human keratin 14.
Species Reactivity: Human, Mouse, and Rat. Others not known.
Positive Control: A431 cells. Skin or Squamous cell carcinoma.
Specificity: Anti-CK14 is useful in differentiating squamous cell carcinomas from poorly differentiated epithelial tumors. Anti-CK14 is one of the specific basal markers for distinguishing between basal and non-basal subtypes of breast carcinomas. Anti-CK14 is also a good marker for differentiation of intraductal from invasive salivary duct carcinoma by the positive staining of basal cells surrounding the in-situ neoplasm as well as for the differentiation of benign prostate from prostate carcinoma. Furthermore, this antibody has been useful in separating oncocytic tumors of the kidney from its renal mimics, and in identifying metaplastic carcinomas of the breast.