CD56 / NCAM1 / NKH1 (Neuronal Cell Marker); Clone 123C3.D5 & 123A8 (Concentrate)
Immunogen: Membrane preparation of a small cell lung carcinoma (123C3.D5 & 123A8)
Clone: 123C3.D5 & 123A8
Isotype: IgG1, kappa (123C3.D5); IgG1, kappa (123A8)
Species Reactivity: Human. Others not known.
Positive Control: Cerebellum, Pancreas, Neuroblastoma.
Specificity: This antibody reacts with an extracellular domain of CD56/NCAM. Anti-CD56 recognizes two proteins of the neural cell adhesion molecule, the basic molecule expressed on most neuroectodermally derived tissues and neoplasms (e.g. retinoblastoma, medulloblastomas, astrocytomas, neuroblastomas, and small cell carcinomas). It is also expressed on some mesodermally derived tumors (rhabdomyosarcoma). Anti-CD56 plays an important role in the diagnosis of nodal and nasal NK/T-cell lymphomas.