S100 (Astrocyte Marker); Clone 4C4.9 (Concentrate)
Immunogen: Purified bovine brain S100 protein
Isotype: IgG2a, kappa
Species Reactivity: Human, Mouse, Rat, Cow. Others not known.
Positive Control: Brain and Melanoma.
Specificity: S-100 protein has been found in normal melanocytes, Langerhans cells, histiocytes, chondrocytes, lipocytes, skeletal and cardiac muscle, Schwann cells, epithelial and myoepithelial cells of the breast, salivary and sweat glands, as well as in glial cells. Neoplasms derived from these cells also express S-100 protein, albeit non-uniformly. A large number of well-differentiated tumors of the salivary gland, adipose and cartilaginous tissue, and Schwann cell-derived tumors express S-100 protein. Almost all malignant melanomas and cases of histiocytosis X are positive for S-100 protein.