CDX2 (GI Epithelial Marker); Clone CDX2/1690 (Concentrate)
Immunogen: Recombinant human CDX2 protein fragment (aa150-249) (exact sequence is proprietary)
Isotype: IgG2a, kappa
Species Reactivity: Human. Others not known.
Positive Control: HT29 cells or Colon Carcinoma.
Specificity: Anti-CDX2 has been useful to establish GI origin of metastatic adenocarcinomas and carcinoids and is especially useful to distinguish metastatic colorectal adenocarcinoma from lung adenocarcinoma. However, mucinous carcinomas of the ovary also express CDX2 protein. It limits the usefulness of this marker in the distinction of metastatic colorectal adenocarcinoma from mucinous carcinoma of the ovary.