TAG-72 / CA72.4 (Tumor-Associated Glycoprotein); Clone SPM148 (Concentrate)
Immunogen: Membrane-enriched fraction of a human breast carcinoma liver metastasis.
Isotype: IgG1, kappa.
Species Reactivity: Reacts with human, cow, dog, hamster, and rat. Others not known.
Positive Control: Jurkat cells. Breast or lung carcinoma.
Specificity: Recognizes an oncofetal antigen of 220kDa, identified as a tumor-associated glycoprotein (TAG-72) with properties of a mucin. Studies have reported that this antibody has 80% sensitivity and 93% specificity for pulmonary adenocarcinoma. Therefore, TAG-72 is a useful marker to distinguish between mesothelioma and adenocarcinoma. However, false positive reactions can occur so results must be interpreted with the utmost caution.