MUC1 / EMA / CD227 (Epithelial Marker); Clone 139H2 (Concentrate)
Immunogen: Human milk-fat globule membranes
Isotype: IgG1, kappa
Species Reactivity: Human and Mouse. Others not known.
Positive Control: MCF-7 or MDA-231 cells. Breast or colon carcinoma.
Specificity: 139H2 reacts with MUC1, a large transmembrane glycoprotein expressed on the ductal surface of normal glandular epithelia. The dominant epitope of 139H2 has not yet been determined. In immunohistochemical assays, it superbly stains routine formalin/paraffin carcinoma tissues. An antibody to MUC1 is useful as a pan-epithelial marker for detecting early metastatic loci of carcinoma in bone marrow or liver.