TAG-72 (Tumor-Associated Glycoprotein); Clone B72.3 (Concentrate)
Immunogen: Membrane-enriched fraction of a human breast carcinoma liver metastasis
Isotype: IgG1, kappa
Species Reactivity: Human, Cow, Dog, Hamster, and Rat. Others not known.
Positive Control: Jurkat cells, breast or lung carcinoma.
Specificity: Recognizes an oncofetal antigen of 220kDa, identified as a tumor-associated glycoprotein (TAG-72) with properties of a mucin. This antibody defines the mucin-carried sialylated-Tn epitope. TAG-72 is usually expressed by adenocarcinomas, but is negative in mesotheliomas. Studies have reported that this antibody has 80% sensitivity and 93% specificity for pulmonary adenocarcinoma. Therefore, TAG-72 is a useful marker to distinguish between mesothelioma and adenocarcinoma. However, false positive reactions can occur, so results must be interpreted with the utmost degree of caution.