CDX-2 & CEA Multiplex Cocktail; Clones EP25 & COL-1 (Ready-To-Use)
Species: Rabbit and Mouse
Designation: Cocktail of Rabbit and Mouse Monoclonal Antibodies to CDX-2 and CEA.
Immunogen: Rabbits were injected with a synthetic peptide corresponding to residues near the C-terminus of human CDX-2. BALB/C mice were injected with Human colon carcinoma cell extracts (CEA).
Mol. Weight: Unknown
Clone: EP25 & COL-1
Isotype: Rabbit IgG and Mouse IgG1, respectively.
Species Reactivity: Human
Positive Control: CDX-2: Colon for normal tissue and colon adenocarcinoma for abnormal tissue.
CEA: Adenocarcinoma of colon, intestine, ovary, lung, cervix, gallbladder, stomach.
Specificity: CDX-2 expression is restricted to nuclear staining in positive cells while CEA expression is restricted mostly to the lumen of colorectal crypts. The CEA antibody (COL-1) shows no reaction with a variety of normal tissues. CEA is not found in benign glands, stroma, or malignant prostatic cells. CEA positivity is seen in adenocarcinomas from the lung, colon, stomach, esophagus, gallbladder, urachus, salivary gland, ovary, and endocervix.