CD138 / Syndecan-1 (SDC1) (Plasma Cell Marker); Clone SDC1/7183
Species: Mouse
Immunogen: Recombinant fragment (around aa1-250) of human CD138 protein (exact sequence is proprietary)
Clone: SDC1/7183
Isotype: IgG1 / Kappa
Entrez Gene ID: 6382
Hu Chromosome Loc.: 2p24.1
Synonyms: Syndecan-1, Heparan Sulfate Proteoglycan Fibroblast Growth Factor Receptor; SDC1; SYND1; Syndecan Proteoglycan 1; Syndecan-1
Mol. Weight of Antigen: 85kDa
Format: 200ug/ml of antibody purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM
PBS with 0.05% BSA & 0.05% azide.
Specificity: Recognizes a protein of 85kDa corresponding to CD138 .
Background: CD138, also designated syndecan-1, is a member of the syndecan family of four transmembrane spanning proteins capable of binding to heparan sulfate and chondroitin sulfate molecules. The syndecans main functions are to control cell growth and differentiation as well as to maintain cell adhesion and cell migration. Under normal conditions CD138 is predominantly expressed on mature plasma cells and early preB-cells, while other haematolymphoid cells are negative. Various types of epithelial cells are also CD138 positive. Squamous epithelial cells show strong membranous and some cytoplasmic staining, except for the mature superficial squamous epithelial cells which are unstained. Mature mesenchymal and neural tissues are not stained. Among haematolymphoid neoplasms, CD138 is expressed in practically all cases of plasma cell malignancies. Among non-haematolymphoid neoplasms the expression of CD138 is found in various types of carcinomas.
Species Reactivity: Human
Positive Control: Human tonsil or lymph node.
Cellular Localization: Cell surface.
Titer/ Working Dilution: Immunohistochemistry (Frozen and Formalin-fixed): 1-2 µg/ml
Microbiological State: This product is not sterile.