CD19 (B-Lymphocyte Marker); Clone CD19/7665
Species: Mouse
Immunogen: Recombinant fragment of human CD19 protein (around aa1-300) (exact sequence is proprietary)
Clone: CD19/7665
Isotype: IgG1 / Kappa
Entrez Gene ID: 930
Hu Chromosome Loc.: 16p11.2
Synonyms: B-lymphocyte antigen CD19, B-lymphocyte surface antigen B4, Differentiation antigen CD19, T-cell surface antigen Leu-12, B-lymphocyte antigen CD19; B-lymphocyte surface antigen B4; CVID3; Leu-12; T-cell surface antigen Leu-12
Mol. Weight of Antigen: 95kDa
Format: 200ug/ml of antibody purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM
PBS with 0.05% BSA & 0.05% azide.
Specificity: Recognizes CD19, a transmembrane glycoprotein that contains two extracellular immunoglobulin-like domains.
Background: CD19 is present in both benign and malignant B-cells and is considered to be the most reliable surface marker of this lineage over a wide range of maturational stages. In normal lymphoid tissue, CD19 is observed in germinal centers, in mantle zone cells, and in scattered cells of the inter-follicular areas. Anti-CD19 exhibits an overall immunoreactivity pattern similar to those of the antibodies against CD20 and CD22. However, in contrast to CD20, expression of CD19 is continuous throughout B-cell development and through terminal differentiation of B-cells into plasma cells. Anti-CD19 positivity is seen in the vast majority of B-cell neoplasms commonly at a lower intensity than normal B-cell counterparts. Plasma cell neoplasms are nearly always negative, as are T-cell neoplasms.
Species Reactivity: Human
Positive Control: Human tonsil, lymph node or spleen.
Cellular Localization: Cell surface
Titer/ Working Dilution: Immunohistochemistry (Frozen and Formalin-fixed): 1-2 µg/ml
Microbiological State: This product is not sterile.