CD27 (Tumor Necrosis Factor Receptor Superfamily 7); Clone LPFS2/4178
Species: Mouse
Immunogen: Recombinant human CD27 protein fragment (aa 28-170) (exact sequence is proprietary)
Clone: LPFS2/4178
Isotype: IgG1 / Kappa
Entrez Gene ID: 939
Hu Chromosome Loc.: 12p13
Synonyms: CD27 antigen, CD27L receptor, T-cell activation antigen CD27, T14, Tumor necrosis factor receptor superfamily member 7, LPFS2; S152; T cell activation antigen S152; T-cell activation antigen CD27; T14; TNFRSF7; TNFSF7; Tp55; Tumor necrosis factor receptor superfamily member 7
Mol. Weight of Antigen: 120kDa
Format: 200ug/ml of antibody purified from Bioreactor Concentrate by Protein A/G. Prepared in 10mM
PBS with 0.05% BSA & 0.05% azide.
Specificity: Recognizes a protein of a disulfide-linked 120kDa dimer, identified as CD27.
Background: It is expressed on the majority of peripheral T cells, medullary thymocytes, memory-type B cells, and natural killer cells. It is a transmembrane phosphoglycoprotein that belongs to the tumor necrosis factor receptor (TNFR) superfamily. CD27 binds to its ligand CD70, a member of the TNF family, and induces T-cell co-stimulation and B-cell activation. It also interacts with TRAFs and is involved in activation of NF B and SAPK/JNK and induces apoptosis.
Species Reactivity: Human
Positive Control: Raji, Ramos cells. Human peripheral blood lymphocytes. Human tonsil and stomach tissues.
Cellular Localization: Membrane
Titer/ Working Dilution: Immunohistochemistry (Frozen and Formalin-fixed): 1-2µg/ml
Western Blotting: 2-4µg/ml
Microbiological State: This product is not sterile.